Is Biological Age a Better Indicator than Chronological Age for Metabolic Health?
Keywords:
Biological age, Chronological age, HOMA IR, Metabolic syndrome, PCOS
Abstract
Our earlier studies have shown more advanced biological age than chronological age in obese women ≥ 40 years of age and particularly with greater visceral obesity. Advancement of age was also seen in women with Polycystic Ovarian Syndrome. Both obesity and Polycystic Ovarian Syndrome patients are known to be associated with metabolic dysfunction with underlying insulin resistance. Since metabolic syndrome is highly prevalent in Indian population, there is a pressing need for in-depth studies about how advancement of biological age over chronological age impacts health and longevity. In this article, we limit the review to the definition, dimensions, markers and predictors of biological aging.
References
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2. Yoo J, Kim Y, Cho EO, Jee SH. Biological age as a useful index to predict seventeen-year survival and mortality in Koreans. BMC Geriatrics. 2017;17:7.
3. Waziry R, Gras L, Sedaghat S, Tiemeier H, Weverling GJ, Ghanbari M, Klap J, de Wolf F, A, Ikram MA, Goudsmit J. Quantification of biological age as a determinant of age‑related diseases in the Rotterdam Study: a structural equation modelling approach. European Journal of Epidemiology. 2019;34:793-99.
4. Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The Critical Role of Metabolic Pathways in Aging. Diabetes. 2012;61(6):1315-22.
5. Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andrés V. Biological Versus Chronological Aging. J Am Coll Cardiol. 2020;75:919–30.
6. Agashe S. Advanced Body Age and Its Correlation with Indices of Metabolic Dysfunction in Patients of Polycystic Ovarian Syndrome. Unpublished MSc dissertation submitted to Indira Gandhi Open University, 2020.
7. Vaidya RA, Pandey SN, Vaidya ADB. Polycystic ovary syndrome: Is it a chronic inflammatory disease? Chapt. 3, ECAB Clinical Update: Obstetrics and Gynecology. 2008;1:42-73.
8. Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE.
Quantification of biological aging in young adults. Proc Natl Acad Sci U S A. 2015;112(30):E4104-10.
9. Jylhävä J, Pedersen NL, Hägg S. Biological Age Predictors. EBioMedicine.2017; 21:29–36.
10. Salomon I, Levinei ME, Schaefer JD, Sugdenc K, Williams B, Yashin AI, Poultonj R, Moffitt TE. Quantification of biological aging in young adults. Proc Natl Acad Sci U S A.
2015;112(52):E7164-5.
11. Hsu GH. Effective health age resulting from metabolic condition changes and lifestyle maintenance program. MOJ Gerontol Ger. 2020;5(3):92?94.
12. Earls JC, Rappaport N, Heath L, Wilmanski T, Magis AT, Schork NJ, Omenn GS, Lovejoy J, Hood L, Price ND. Multi- Omic Biological Age Estimation and Its Correlation With
Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals. The Journals of Gerontology: Series A. 2019;74(1):S52–S60.
13. Bae C-Y, Piao M, Kim M, Im Y, Kim S, Kim D, Choi J , Cho KH. Biological age and lifestyle in the diagnosis of metabolic syndrome: the NHIS health screening data, 2014–2015.Sci Rep. 2021;11:444.
14. Nakamura, E., Moritani, T. & Kanetaka, A. Biological age versus physical fitness age. Eur. J. Appl. Physiol. Occup. Physiol. 1989;58(7):778–85.
Published
2021-02-27
How to Cite
Shubhada V Agashe, Shobha A Udipi, Rama A Vaidya, Ashok DB Vaidya. (2021). Is Biological Age a Better Indicator than Chronological Age for Metabolic Health?. The Indian Practitioner, 74(2), 29-31. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1122
Section
Review article
