From Darkness to Light: Clinical Insights on Melatonin
Keywords:
Melatonin, sleep disorders, pleiotropic benefits, therapeutic benefits
Abstract
Melatonin also known as ‘sleep hormone’ is synthesized and released from the pineal gland in response to the luminous information. Melatonin primarily contributes to the regulation of biological rhythms and induction of sleep. Apart from this, due to its inherent anti-oxidant property, it is known to impart protection to various tissues. In addition, it also exhibits multiplicity of physiological effects all over the body. At therapeutic level, Melatonin is used for the management of primary as well as secondary sleep disorders, jet lag, and synchronization of cardiac rhythms. Additionally, due to its pleiotropic benefits it is used in various disorders.
Conflict of Interest: Dr.Manish Maladkar, Dr. Ashok Yadav and Sonal Kamble are employed by Aristo Pharmaceuticals Private Limited, India.
Source of Support: None declared
References
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2. Pevet P. Melatonin Dialogues in Clinical Neuroscience. 2002; 4:57-72.
3. Tordjman S, Chokron S, Delorme R, et al. Current Neuropharmacology. 2017; 15:434- 443.
4. Emet M, Ozcan H, Yayla M, et al. A Review of Melatonin, Its Receptors and Drugs. Eurasian J Med. 2016; 48:135-41.
5. Feingold KR, Anawalt B, Boyce A, et al. Physiology of the Pineal Gland and Melatonin – Endotext. 2000.
6. Srinivasan V, Trahkt I, Spence D, et al. Melatonin and melatonergic drugs on Sleep: possible mechanisms of action. International Journal of Neuroscience. 2009; 119:821-846.
7. Khullar A. The Role of Melatonin in the Circadian Rhythm Sleep-Wake Cycle. Psychiatric Times. 2012; 29:1-8.
8. Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation British Journal of Pharmacology. 2018; 175:3190–3199.
9. ZizhenXie, Fei Chen, William A, et al. A review of sleep disorders and melatonin. Neurological Research. 2017:1-8.
10. Shechter A, Lespérance P, Ying Kin N, et al. Nocturnal polysomnographic sleep across the menstrual cycle in premenstrual
dysphoric disorder Sleep Med. 2012;13:1071–1078.
11. Scheer F, Morris C, Garcia J, et al. Repeated Melatonin Supplementation Improves Sleep in Hypertensive Patients Treated with Beta-Blockers: A Randomized Controlled TrialSleep. 2012; 35:1395–1402.
12. Lemoine J, Nir T, Laudon M, et al. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. 2007; 16:372-380.
13. Luthringer R, Muzet M, Zisapel N, et al. The effect of prolonged- release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia IntClinPsychopharmacol. 2009; 24:239-249.
14. Wade A G, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007; 23:2597-2605.
15. Roberto C, Mendonça L, Nicolas A, et al. The benefits of four weeks of melatonin treatment on circadian patterns in resistance-trained athletes. Chronobiology International. 2015; 32:1125–1134.
16. Mundey K, Benloucif S, Harsanyi K, et al. Phase-Dependent Treatment of Delayed Sleep Phase Syndrome with Melatonin. Sleep. 2005; 28:1271-1278.
17. Dahlitz M, Alvarez B, Vignau J, et al. Delayed sleep phase syndrome response to melatonin. Lancet. 1991; 337:1121- 1124.
18. Kayumov L, Brown G, Jindal R, et al. A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome. Psychosom Med. 2001; 63:40e8.
19. Haghighi K S, Aminian O, Pouryaghoub G, et al. Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial J Circadian Rhythms. 2008; 6:1-5.
20. Sack R, Auckley D, Auger R, et al. Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders. Sleep. 2007; 0:1460-83.
21. Herxheimer A, Petrie K. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002:1-9.
Published
2021-08-30
How to Cite
Dr. Manish Maladkar, Dr. Ashok Yadav, Sonal Kamble. (2021). From Darkness to Light: Clinical Insights on Melatonin. The Indian Practitioner, 74(8), 30-36. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1232
Section
Review article
