Screening of Diabetic Patients for Non-Alcoholic Fatty Liver Disease Based on Liver Indices: A Retrospective Cross-Sectional Study

  • Dr. Anand Shindikar, Dr. Anushree Mehta, Dr. Ashwinikumar Raut, Dr. Rama Vaidya
Keywords: Hepatic Steatosis Index, Fibrosis score, Non-Alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis

Abstract

Background and Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) includes a wide spectrum of liver pathophysiology, ranging between relatively benign Nonalcoholic fatty liver to a serious pathology like fibrosis and cirrhosis. NAFLD is commonly associated with Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome and may increase the risk for mortality.
American Diabetes Association and European Association for the study of Diabetes have recommended screening of all T2DM patients for NAFLD.
Materials and Methods: We did a retrospective analysis of medical records of T2DM patients who attended a diabetes clinic as ambulant patients for 1 year. Out of 215 patients, complete demographic, haemodynamic and biochemical data was available for 46 patients. Simple liver indices like Hepatic Steatosis Index (HSI) and Fibrosis score (FIB-4) were computed.
Results: Presence of steatosis was observed in30 patients based on HSI > 36. Out of these, intermediate risk of advanced fibrosis was observed in 4 patients based on FIB-4 > 1.3.
Conclusion: HSI based screening for steatosis and FIB-4 based screening for fibrosis should be part of liver monitoring in patients with type 2 diabetes mellitus to identify individuals with higher risk for NAFLD.

References

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2. Mitra S. Diabetes Research, Prevalence, and Intervention in India. European Journal of Environment and Public Health 2019, 3(1), 1-5. Available at, tp://dx.doi.org/10.20897/ejeph/4004
3. Dharmalingam M and Yamasandhi PG. Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.Indian J Endocrinol Metab. 2018; 22(3): 421-428.doi: 10.4103/ijem. IJEM_585_17, PMCID: PMC6063173PMID: 30090738
Published
2023-03-06
How to Cite
Dr. Anand Shindikar, Dr. Anushree Mehta, Dr. Ashwinikumar Raut, Dr. Rama Vaidya. (2023). Screening of Diabetic Patients for Non-Alcoholic Fatty Liver Disease Based on Liver Indices: A Retrospective Cross-Sectional Study. The Indian Practitioner, 76(2), 21-25. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1498