Dapagliflozin and Neuro-nutrition: A Pragmatic Approach to Manage Diabetic Peripheral Neuropathy
Keywords:
Type 2 Diabetes (T2DM), Diabetic peripheral neuropathy (DPN), Dapagliflozin, Neuro-nutrition, B-group vitamins, Neuroprotection
Abstract
Diabetic peripheral neuropathy (DPN) is the most prevalent microvascular complication of diabetes mellitus. DPN results from a complex interaction of factors including hyperglycemia, glucotoxicity, increased intracellular glucose concentration induced mitochondrial dysfunction, oxidative stress, etc. A multifaceted approach is warranted for the clinical treatment of DPN. Combination therapy of an antidiabetic agent along with neuro-nutrition aimed at addressing the pathogenic features of neuropathy can be a potential treatment option for effective management of DPN.
References
1. Zimmet PZ, Diabetes and its Drivers: the Largest Epidemic in Human History? Clin. Diabetes Endocrinol;p.3 (1), 1–8.
2. IDF. Diabetes Facts & Figures, the IDF Diabetes Atlas Ninth Edition 2019.
3. Bromberg MB, An Approach to the Evaluation of Peripheral Neuropathies. Seminars in Neurology, 25. p. 153-159.
2. IDF. Diabetes Facts & Figures, the IDF Diabetes Atlas Ninth Edition 2019.
3. Bromberg MB, An Approach to the Evaluation of Peripheral Neuropathies. Seminars in Neurology, 25. p. 153-159.
Published
2023-03-06
How to Cite
Dr. Manish Maladkar, Dr. Shrikant Patil, Dr. Ashok Yadav. (2023). Dapagliflozin and Neuro-nutrition: A Pragmatic Approach to Manage Diabetic Peripheral Neuropathy. The Indian Practitioner, 76(2), 28-30. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1508
Section
Clinical Practice
