Heart-type Fatty Acid-binding Protein (H-FABP) as an Early Diagnostic and Reperfusion Biomarker in Patients with Acute Chest Pain and its Correlation with Echocardiographic Left Ventricular Ejection Fraction and Angiographic Spectrum of Coronary Vessels

Abstract

Background and Aims: Heart-type fatty acid-binding protein (H-FABP) is a novel marker of myocardial injury, released rapidly (<1 h) after the onset of myocardial injury and plays an important role in both early diagnoses of high-risk patients presenting with chest pain as well as an early reperfusion marker in post-thrombolytic patients. We aim to assess and compare the efficacy of H-FABP as an early marker of cardiac injury with Troponin I (cTnI) and creatinine Phospholinase Kinase (CPK-MB) and to correlate it with Left ventricular Ejection Fraction (LVEF)and percentage of stenosis in Coronary arteries.

Material and Methods: Total of 300 patients (STEMI 150 and NSTEMI 150) with acute chest pain attending the emergency department within 6 hours after the onset of chest pain were included. Peripheral venous blood samples were obtained on admission, post thrombolysis at 60 minutes, and after 6 and 12 hours to measure a panel of conventional biomarkers FABP, cTnI and CPK. Echocardiography assessed Simpson’s LVEF and Trans mitral Doppler flow and the spectrum of coronary artery disease was defined by Coronary Angiography.

Conclusion: FABP could reliably diagnose AMI patients 1 to 3 hours after admission over CPK MB and Troponin I and could also assess post-thrombolysis reperfusion in STEMI patients noninvasively over coronary angiography.

Conflict of Interest: None declared

Source of Support: None declared