COPD – Trends and Updates in Management
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disorder characterized by airway abnormalities which lead to persistent and often progressive airflow obstruction. COPD is compounded with complex pathophysiology, involving interplay of several environmental and genetic risk factors. Patients present with chronic respiratory symptoms of progressive dyspnea, cough, and sputum production, which, if inadequately treated, are often associated with exacerbations and hospitalization. With an ageing population and exposure to tobacco smoke and/or air pollutants, the burden of COPD is only expected to increase in the coming years in our state and country. Already it is the third leading cause of mortality and is expected to become the second by 2030. Management modalities are currently centered on relieving symptoms of airway obstruction, delaying decline in lung function, reducing exposureto risk factors like tobacco smoke, infections and increasing respiratory muscle strength through interventions like nutrition and rehabilitation on the other.
References
2. Verma A, Gudi N, Yadav UN, Roy MP, Mahmood A, Nagaraja R, et al. Prevalence of COPD among population above 30 years in India: A systematic review and meta-analysis. J Glob Health. 2021;11:1–13.
3. Jindal SK, Aggarwal AN, Gupta D, Agarwal R, Kumar R, Kaur T, et al. Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). Int J Tuberc Lung Dis. 2012 Sep;16(9):1270-7.
4. Dhar R, Jindal SK. Occupational exposures and COPD: Significant issues in the Indian subcontinent. Respirology. John Wiley and Sons Inc; 2022; 27:462–4.
5. Dhar R, Nair G, Jana R, Shah A, Dalal A, Rajagopala S, et al. Phenotyping Post TB Obstructive airways disease (TOPD) in India. European Respiratory Journal [Internet]. 54(suppl 63):PA734.
6. Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016 Jul;138(1):16-27.
7. Gagnon P, Guenette JA, Langer D, Laviolette L, Mainguy V, Maltais F, et al. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014 Feb 15;9:187-201.
8. Smith J, Woodcock A. Cough and its importance in COPD. Int J Chron Obstruct Pulmon Dis. 2006;1(3):305-14.
9. Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009 Sep;34(3):648-54.
10. van Schayck, O., Rabe, K. & Rudolf, M. COPD: The role of primary care in effective diagnosis, treatment and management. Prim Care Respir J 2003;12:16–20.