Forty-eight Percent of Cancers are Associated with Preventable Risk Factors–This is a Wake-Up Call for All Indian Practitioners!
Keywords:
Cancer Risk Prevention; Cancer prevention; Cancer Risk Factors
Abstract
Recent global analysis of cancers has shown that 48% of cancers are associated with Preventable Risk Factors. In India almost half of all cancers in the country are detected in the productive age group of 40 to 64 years. This revelation should put all practitioners on the alert to detect preventable risk factors for cancers in all individuals above 40 and to promote risk reduction in practice.
References
1. Sung H, Ferlay J, Siegel RL et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338.
2. Mathur P, Nallasamy V, John A et al on behalf of ICMR-NCDIR-NCRP. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. Journal of Clinical Oncology (JCO) Global Oncology. 2020;6 https://doi.org/10.1200/GO.20.00122
3. Nayak MG, George A, Vidyasagar MS et al. Quality of Life among Cancer Patients. Indian J Palliat Care. 2017;23:445-450. doi: 10.4103/IJPC.IJPC_82_17. PMID: 29123353; PMCID: PMC5661349.
4. Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever‐increasing importance of cancer as a leading cause of premature death worldwide. Cancer.2021;127:3029‐3030. doi:10.1002/cncr.335872.
5. Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P. Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme, India. Indian J Med Res. 2022;156(4&5):598-607. doi: 10.4103/ijmr.ijmr_1821_22.
6. GBD 2019 Cancer Risk Factors Collaborators. The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2022; 400:563-591. doi: 10.1016/S0140-6736(22)01438-6.
7. Wong WK. Multistep tumorigenesis. Chapter 11. In: The Biology of Cancer. Ed. Weinberg RA, Garland Science, 2007:399-462.
8. Gopika M. G; Prabhu Priya R, Thulaseedharan, Jissa V. Status of cancer screening in India: An alarm signal from the National Family Health Survey (NFHS-5). Journal of Family Medicine and Primary Care 2022;11:7303-7307. DOI: 10.4103/jfmpc.jfmpc_1140_22
9. https://www.mea.gov.in/press-releases.htm?dtl/38318/Prime_Minister_attends_Quad_Cancer_Moonshot_event#:~:text=As%20India's%20contribution%20to%20the,in%20the%20Indo%2DPacific%20region (2024).
10. McInerney KA, Hatch EE, Wesselink AK, Mikkelsen EM, Rothman KJ, Perkins RB, Wise LA. The Effect of Vaccination Against Human Papillomavirus on Fecundability. Paediatr Perinat Epidemiol. 2017;31:531-536. doi: 10.1111/ppe.12408.
11. Garolla A, De Toni L, Bottacin A, Valente U, De Rocco Ponce M, Di Nisio A, Foresta C. Human Papillomavirus Prophylactic Vaccination improves reproductive outcome in infertile patients with HPV semen infection: a retrospective study. Sci Rep. 2018;8:912. doi: 10.1038/s41598-
018-19369-z. PMID: 29343824
12. Garolla A, Mereu S, Pizzol D, Yon DK, Rahmati M, Soysal P, Ilie PC, Bertoldo A, Trott M, Smith L. Papillomavirus infection and male infertility: A systematic review and meta-analysis. Health Sci Rep. 2024;7:e70048. doi: 10.1002/hsr2.70048.
13. Winn AN,Ekwueme DU, Guy Jr. GP, Neumann PJ. Cost-Utility Analysis of Cancer Prevention, Treatment, and Control: A Systematic Review. Am J Prev Med. 2016;50:241–248. doi:10.1016/j.amepre.2015.08.009.
14. Chen S, Cao Z, Prettner K, et al. Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050. JAMA Oncol. 2023;9:465‐472.
15. Emmons KM, McBride CM, Puleo E et al. Project PREVENT: A Randomized Trial to Reduce Multiple Behavioral Risk Factors for Colon Cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1453–9.
16. https://coloncancerpreventionproject.org/prevent-colon-cancer/- Prevent Colon Cancer.
17. Doumouras AG, Lovrics O, Paterson JM, Sutradhar R, Paszat L, Sivapathasundaram B, Tarride JE, Anvari M. Residual Risk of Breast Cancer After Bariatric Surgery. JAMA Surg. 2023;158:634-641. doi: 10.1001/jamasurg.2023.0530.
18. Falcaro M, Castanon A, Ndelela B et al. The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study. The Lancet, 2021;398:2084 – 2092.
19. Joo JK, Shin JH, Lee JR, Kim MR. Levonorgestrel-Releasing Intrauterine System Use in Perimenopausal Women. J Menopausal Med. 2021;27:49-57. doi: 10.6118/jmm.20038.
20. Büttner-Teleagă A, Kim YT, Osel T, Richter K. Sleep Disorders in Cancer-A Systematic Review. Int J Environ Res Public Health. 2021;18:11696. doi: 10.3390/ijerph182111696. PMID: 34770209.
21. Nagendra HR. Cancer: Prevention and Rehabilitation through Yoga. Int J Yoga. 2018;11:1-2. doi: 10.4103/ijoy.IJOY_71_17.
22. Shilpa Chandran S, Chetambath R. Changing trends in lung cancer epidemiology. The Indian Practitioner 2023;75: 24-26.
23. Mohan A, Garg A, Gupta A et al. Clinical profile of lung cancer in North India: A 10-year analysis of 1862 patients from a tertiary care center. Lung India. 2020;37:190-97. DOI: 10.4103/ lungindia. 333_19.
24. Vaidya AB, Vaidya RA, Vaidya VA, Vaidya G, Joshi BA, Mody J, Joshi JV, Amonkar AA, Sirsat SM.Spontaneous or induced regression of cancer. Ancient Science of Life, 2003;22:75-83.
25. Hastak K, Lubri N, Jakhi SD, More C, John A, Ghaisas SD, Bhide SV.Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Letters 1997;116:265-269.
26. Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB. Chemopreventive Potential & Safety Profile of NBFR-03 (Supercritical Curcuma longa exract) in Women with Cervical Low- Grade Squammous Intraepithelial Neoplasia in Papanicolaou Smears. Asian Pacific J
Cancer Prevention 2011;12,3305-3311.
27. Joshi JV, Paradkar PH, Jagtap S, Paradkar H, Walwatkar P, Soman G. Persistent chemopreventive action of integrative treatment of Low-Grade Cervical Intraepithelial Neoplasia- Case series. Journal of Ayurveda and Integrative Medicine 2016;7:109-112.
28. Joshi JV, Jagtap SS, Rastogi N, Walwatkar P, Nabar NS, Hingorani L, Vaidya AB. Integrated Non-invasive Management of Cervical Low-Grade Squamous Intraepithelial Lesions Observed in Papanicolaou Smears with Antimicrobials Followed by Oral Curcuma Longa Extract. Asian
Pacific J Cancer Biology2020;5:89-97.
29. Raut A, Dhami-Shah H, Phadke A, Shindikar A, Udipi S, Joshi J, Vaidya R, Vaidya ADB. Picrorhiza kurroa, Royle ex Benth:Traditional uses, phytopharmacology, and translational potential in therapy of fatty liver disease. J Ayurveda Integr Med. 2023 Jan-Feb;14(1):100558. doi:
10.1016/j.jaim.2022.100558. Epub 2022 Jun 2.
30. Dhamija, Ekta1; Paul, Shashi Bala1,; Kedia, Saurabh2. Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: An increasing concern. Indian Journal of Medical Research 2019; 149:9-17. | DOI: 10.4103/ijmr.IJMR_1456_17
31. Gore S, Deshpande D, Bhuvad S, Tilekar P, Awalkanthe S, Sharma B, Sardeshmukh S, Deshmukh V. Effectiveness of adjunct ayurvedic treatment in cancer control, and improving well-being in rare and advanced cancers. Journal of Ayurveda and Integrative Medicine. 2018, 9.
10.1016/j.jaim.2018.02.126.
32. Girisa S, Kumar A, Kunnumakkara AB. (2023). Curcumin as a Chemopreventive Agent for Oral Submucous Fibrosis. In: Warnakulasuriya, S., Ranganathan, K. (eds) Oral Submucous Fibrosis. Textbooks in Contemporary Dentistry. Springer, Cham 2023.
https://doi.org/10.1007/978-3-031-12855-4_17
2. Mathur P, Nallasamy V, John A et al on behalf of ICMR-NCDIR-NCRP. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. Journal of Clinical Oncology (JCO) Global Oncology. 2020;6 https://doi.org/10.1200/GO.20.00122
3. Nayak MG, George A, Vidyasagar MS et al. Quality of Life among Cancer Patients. Indian J Palliat Care. 2017;23:445-450. doi: 10.4103/IJPC.IJPC_82_17. PMID: 29123353; PMCID: PMC5661349.
4. Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever‐increasing importance of cancer as a leading cause of premature death worldwide. Cancer.2021;127:3029‐3030. doi:10.1002/cncr.335872.
5. Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P. Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme, India. Indian J Med Res. 2022;156(4&5):598-607. doi: 10.4103/ijmr.ijmr_1821_22.
6. GBD 2019 Cancer Risk Factors Collaborators. The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2022; 400:563-591. doi: 10.1016/S0140-6736(22)01438-6.
7. Wong WK. Multistep tumorigenesis. Chapter 11. In: The Biology of Cancer. Ed. Weinberg RA, Garland Science, 2007:399-462.
8. Gopika M. G; Prabhu Priya R, Thulaseedharan, Jissa V. Status of cancer screening in India: An alarm signal from the National Family Health Survey (NFHS-5). Journal of Family Medicine and Primary Care 2022;11:7303-7307. DOI: 10.4103/jfmpc.jfmpc_1140_22
9. https://www.mea.gov.in/press-releases.htm?dtl/38318/Prime_Minister_attends_Quad_Cancer_Moonshot_event#:~:text=As%20India's%20contribution%20to%20the,in%20the%20Indo%2DPacific%20region (2024).
10. McInerney KA, Hatch EE, Wesselink AK, Mikkelsen EM, Rothman KJ, Perkins RB, Wise LA. The Effect of Vaccination Against Human Papillomavirus on Fecundability. Paediatr Perinat Epidemiol. 2017;31:531-536. doi: 10.1111/ppe.12408.
11. Garolla A, De Toni L, Bottacin A, Valente U, De Rocco Ponce M, Di Nisio A, Foresta C. Human Papillomavirus Prophylactic Vaccination improves reproductive outcome in infertile patients with HPV semen infection: a retrospective study. Sci Rep. 2018;8:912. doi: 10.1038/s41598-
018-19369-z. PMID: 29343824
12. Garolla A, Mereu S, Pizzol D, Yon DK, Rahmati M, Soysal P, Ilie PC, Bertoldo A, Trott M, Smith L. Papillomavirus infection and male infertility: A systematic review and meta-analysis. Health Sci Rep. 2024;7:e70048. doi: 10.1002/hsr2.70048.
13. Winn AN,Ekwueme DU, Guy Jr. GP, Neumann PJ. Cost-Utility Analysis of Cancer Prevention, Treatment, and Control: A Systematic Review. Am J Prev Med. 2016;50:241–248. doi:10.1016/j.amepre.2015.08.009.
14. Chen S, Cao Z, Prettner K, et al. Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050. JAMA Oncol. 2023;9:465‐472.
15. Emmons KM, McBride CM, Puleo E et al. Project PREVENT: A Randomized Trial to Reduce Multiple Behavioral Risk Factors for Colon Cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1453–9.
16. https://coloncancerpreventionproject.org/prevent-colon-cancer/- Prevent Colon Cancer.
17. Doumouras AG, Lovrics O, Paterson JM, Sutradhar R, Paszat L, Sivapathasundaram B, Tarride JE, Anvari M. Residual Risk of Breast Cancer After Bariatric Surgery. JAMA Surg. 2023;158:634-641. doi: 10.1001/jamasurg.2023.0530.
18. Falcaro M, Castanon A, Ndelela B et al. The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study. The Lancet, 2021;398:2084 – 2092.
19. Joo JK, Shin JH, Lee JR, Kim MR. Levonorgestrel-Releasing Intrauterine System Use in Perimenopausal Women. J Menopausal Med. 2021;27:49-57. doi: 10.6118/jmm.20038.
20. Büttner-Teleagă A, Kim YT, Osel T, Richter K. Sleep Disorders in Cancer-A Systematic Review. Int J Environ Res Public Health. 2021;18:11696. doi: 10.3390/ijerph182111696. PMID: 34770209.
21. Nagendra HR. Cancer: Prevention and Rehabilitation through Yoga. Int J Yoga. 2018;11:1-2. doi: 10.4103/ijoy.IJOY_71_17.
22. Shilpa Chandran S, Chetambath R. Changing trends in lung cancer epidemiology. The Indian Practitioner 2023;75: 24-26.
23. Mohan A, Garg A, Gupta A et al. Clinical profile of lung cancer in North India: A 10-year analysis of 1862 patients from a tertiary care center. Lung India. 2020;37:190-97. DOI: 10.4103/ lungindia. 333_19.
24. Vaidya AB, Vaidya RA, Vaidya VA, Vaidya G, Joshi BA, Mody J, Joshi JV, Amonkar AA, Sirsat SM.Spontaneous or induced regression of cancer. Ancient Science of Life, 2003;22:75-83.
25. Hastak K, Lubri N, Jakhi SD, More C, John A, Ghaisas SD, Bhide SV.Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Letters 1997;116:265-269.
26. Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB. Chemopreventive Potential & Safety Profile of NBFR-03 (Supercritical Curcuma longa exract) in Women with Cervical Low- Grade Squammous Intraepithelial Neoplasia in Papanicolaou Smears. Asian Pacific J
Cancer Prevention 2011;12,3305-3311.
27. Joshi JV, Paradkar PH, Jagtap S, Paradkar H, Walwatkar P, Soman G. Persistent chemopreventive action of integrative treatment of Low-Grade Cervical Intraepithelial Neoplasia- Case series. Journal of Ayurveda and Integrative Medicine 2016;7:109-112.
28. Joshi JV, Jagtap SS, Rastogi N, Walwatkar P, Nabar NS, Hingorani L, Vaidya AB. Integrated Non-invasive Management of Cervical Low-Grade Squamous Intraepithelial Lesions Observed in Papanicolaou Smears with Antimicrobials Followed by Oral Curcuma Longa Extract. Asian
Pacific J Cancer Biology2020;5:89-97.
29. Raut A, Dhami-Shah H, Phadke A, Shindikar A, Udipi S, Joshi J, Vaidya R, Vaidya ADB. Picrorhiza kurroa, Royle ex Benth:Traditional uses, phytopharmacology, and translational potential in therapy of fatty liver disease. J Ayurveda Integr Med. 2023 Jan-Feb;14(1):100558. doi:
10.1016/j.jaim.2022.100558. Epub 2022 Jun 2.
30. Dhamija, Ekta1; Paul, Shashi Bala1,; Kedia, Saurabh2. Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: An increasing concern. Indian Journal of Medical Research 2019; 149:9-17. | DOI: 10.4103/ijmr.IJMR_1456_17
31. Gore S, Deshpande D, Bhuvad S, Tilekar P, Awalkanthe S, Sharma B, Sardeshmukh S, Deshmukh V. Effectiveness of adjunct ayurvedic treatment in cancer control, and improving well-being in rare and advanced cancers. Journal of Ayurveda and Integrative Medicine. 2018, 9.
10.1016/j.jaim.2018.02.126.
32. Girisa S, Kumar A, Kunnumakkara AB. (2023). Curcumin as a Chemopreventive Agent for Oral Submucous Fibrosis. In: Warnakulasuriya, S., Ranganathan, K. (eds) Oral Submucous Fibrosis. Textbooks in Contemporary Dentistry. Springer, Cham 2023.
https://doi.org/10.1007/978-3-031-12855-4_17
Published
2024-12-12
How to Cite
Dr. Joshi Jayashree V. (2024). Forty-eight Percent of Cancers are Associated with Preventable Risk Factors–This is a Wake-Up Call for All Indian Practitioners!. The Indian Practitioner, 77(11), 21-24. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1816
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Call for Action
