Human Metapneumovirus (HMPV): Overview and Addressing Concerns

  • Dr. Varsha Narayanan
Keywords: HMPV, respiratory infection, flu-like, common-cold, hygiene

Abstract

Human Metapneumovirus (HMPV) is a respiratory virus similar to many other respiratory viruses, and known to cause seasonal outbreaks of acute respiratory infection (ARI), peaking in late winter to early spring. Symptoms like cough, fever, and nasal congestion are seen, similar to the common cold, and sometimes flu-like symptoms and lower respiratory infection can occur especially in very young children or those with chronic respiratory, medical or immunosuppressive conditions. However, hospitalization rates are low and long-term sequelae not seen. Most children are infected by the age of 5 years, but reinfections can occur anytime throughout life. Supportive and symptomatic care usually leads to recovery in around a week. HMPV is an old known virus and has not shown potential to become a pandemic. Therefore, it should not be looked at with the eye of the COVID experience, and all such misplaced information and fear-spreading on media should be curbed. However, the community especially the high-risk groups should always be reminded and guided of general health, hygienic and lifestyle practices that protect against respiratory infections.

 

References

1. Panda S, Mohakud NK, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. Int J Infect Dis. 2014 Aug;25:45-52.
2. Narayanan H, Balaji N, Mageshbabu R, and Kumaran V. A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infection. Asian Journal of Research in Infectious Diseases. 2023;12 (3):37-51.
3. Feng Y, He T, Zhang B. et al. Epidemiology and diagnosis technologies of human metapneumovirus in China: a mini review. Virol J 2024; 21: 59
4. Soto JA, Gálvez NMS, Benavente FM, Pizarro-Ortega MS, Lay MK, Riedel C, et al. Human Metapneumovirus: Mechanisms and Molecular Targets Used by the Virus to Avoid the Immune System. Front Immunol. 2018 Oct 24;9:2466.
5. Keiko Kan-o, Ruben Ramirez, Martin I. MacDonald, Michael Rolph, Penny A. et al. Human Metapneumovirus Infection in Chronic Obstructive Pulmonary Disease: Impact of Glucocorticosteroids and Interferon, The Journal of Infectious Diseases, May 2017; 215 (10):1536–1545.
6. Martinello RA, Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J Infect. 2006 Oct;53(4):248-54.
7. Costa-Filho R.C, Saddy F, Costa J.L.F, Tavares L.R, Castro Faria Neto H.C. The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case. Microorganisms 2025, 13, 73.
8. Centers for Disease Control CDC [Internet]. 2024-2025 Respiratory Disease Season Outlook - December Update. Updated Dec 20, 2024. Accessed Jan 7, 2025. Available from https://www.cdc.gov/cfa-qualitative-assessments/php/data-research/season-outlook24-25-dec-update.html
9. World Health Organization WHO [Internet]. Trends of acute respiratory infection, including human metapneumovirus, in the Northern Hemisphere. Dated and Accessed Jan 7, 2025. Available from https://www.who.int/emergencies/disease-outbreak-news/item/2025-DON550
10. Leung MW, O'Donoghue M, Suen LK. Personal and Household Hygiene Measures for Preventing Upper Respiratory Tract Infections among Children: A Cross-Sectional Survey of Parental Knowledge, Attitudes, and Practices. Int J Environ Res Public Health. 2022 Dec 23;20(1):229.
Published
2025-02-13
How to Cite
Dr. Varsha Narayanan. (2025). Human Metapneumovirus (HMPV): Overview and Addressing Concerns. The Indian Practitioner, 78(01), 5-7. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/1842