To study the Prevalence of Iron Deficiency Anemia in children aged 6 months – 6 years presenting with Febrile Seizures in Department of Pediatrics
Abstract
Abstract
Background:- Febrile seizure is a common cause of seizures in young children but with an excellent prognosis. In addition to genetic predisposition, febrile seizures are generally thought to be induced by elemental changes such as iron deficiency. Regarding the high prevalence of febrile seizures with iron deficiency anemia in children, the aim of our study is to investigate the role of iron deficiency anemia in febrile seizures patients. Iron deficiency (ID) is the most common nutritional deficiency. The peak age for ID is between 1 and 2 years, which coincides with the peak incidence for febrile seizures. Aim: To study the prevalence of iron deficiency anemia in children aged 6 months to 6 years having febrile seizures. Study design: It is a prospective observational case control study. Material & Method: The present study was included 50 children aged 6 months to 6 years with febrile seizures (cases) and 30 febrile children without seizures (controls), coming to Pediatrics OPD and emergency, Rajindra Hospital Patiala. Hemoglobin level (Hb) and serum ferritin levels were estimated in all the patients.
Results: In cases the mean serum ferritin levels was 25.52±2.9 ng/dl and in controls was 61.36±7.7 ng/dl. It was seen that serum ferritin levels were significantly low in children with febrile seizures as compared to controls (p < 0.004).
Conclusion: Prophylactic iron supplementation should be considered in all children who are anemic as it may have a preventable role in febrile seizures.
References
2. Mikati MA. Febrile Seizures. In: Nelson Textbook of Pediatrics. Kliegman RM, Stanton BMD, Geme JS, Schor N, Behrman RE. 19th edn. 2011;586.1:2017.
3. Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C et al. The Association Between Iron Deficiency and Febrile Seizures in Childhood Clinical Pediatrics 2009;48(4)2009:420-26.
4. Bidabadi E, Mashouf M. Association between iron def. Anemia & and first febrile convulsion: A case control study. Seizure 2009;18:347–51.
5. Parks YA, Wharton BA. Iron deficiency and the brain. Acta Paediatr Scand 1989;55(suppl 361):71-7.
6. Auvichayapat P, Auvichayapat N, Jedsrisuparp A, Thinkhamrop B et al. Incidence of Febrile Seizures in Thalassemic Patients. J Med Assoc Thai 2004;87(8):970-3.
7. Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A et al. Iron deficiency anemia and febrile convulsions: case-control study in children under 2 years. BMJ 1996;313(7053):343.
8. Vaswani RK,Dharaskar PG,Kulkarni S, Ghosh K. Iron Deficiency as a Risk Factor for First Febrile Seizure. Indian Pediatr 2010;47:437-39.
9. Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012;49(1):17-9.
10. Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995 Mar;10(2):105-9.
11. Momen AA, Nikfar R, Karimi B. Evaluation of iron status in 9 months to 5 years old children with febrile seizures: a case controle study in south west of Iran. Iran J Child Neurology 2010;4(2):45-50.
12. Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia. 2002;43(7):740-3.
13. Yager JY, Hartfield DS. Neurologic manifestations of iron deficiency in childhood. Pediatr Neurol. 2002;27(2):85-92.
14. Naveed-ur-Rehman, Billoo AG. Association between Iron deficiency anemia and febrile seizures. J Coll Physicians Surg Pak. 2005;15(6):338-40.
15. Miri-Aliabad G, Khajeh A, Arefi M. Iron Status and Iron Deficiency Anemia in Patients with Febrile Seizure. Zahedan J Res Med Sci 2013;15(9):14-17.
16. Boshra A.T. Ahmed. Iron Deficiency as a Risk Factor for Simple Febrile Seizures Med. J. Cairo Univ. 2013;81(2): 51-54.
