Correlation of histopathological and anatomical changes in placenta of intrauterine growth restriction (I.U.G.R)
Abstract
Background: Placenta is a vital organ for maintaining pregnancy and promoting normal growth by transfer of essential nutrients between fetus and mother. Any morphological alteration of placenta affects the growth of fetus leads to intrauterine growth restriction.
Material and methods: This study was conducted in 200 patients with IUGR and 200 normal patients. Gross and histopathological features of placentas of both groups are studied, analysed by student t test and compared with chi square test. p value<.05 was considered significant.
Results: Gross features weight, thickness and calcification in study show significant increase in value(p<0.05) compared to control group and histopathology of placenta also show significant increase in syncytial knots formation, cytotrophoblastic proliferation, stromal fibrosis and calcification in comparison to control group.
Conclusion: To conclude these morphological and histopathological findings of placenta are the etiological bases of I.U.G.R.
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