Delayed Peripheral Neuropathy due to Organophosphate Tri- Ortho-Cresyl Phosphate Poisoning

Vyom Mori, Lakhani K, Makwana D, Shah A, Purohit N, Patel K, Zadafiya H, Hada M, Bhalani N, Goswami S, Patel R, Vala D

Vyom Mori, Lakhani K, Makwana D, Shah A, Purohit N, Patel K, Zadafiya H, Hada M, Bhalani N, Goswami S, Patel R, Vala D

Keywords: Delayed neuropathy, Tri-ortho-cresyl phosphate

Abstract

Introduction: 15 patients were admitted to Civil Hospital, Ahmedabad with complains of cramping pain and weakness in bilateral lower limbs. They were found to be suffering from subacute motor neuropathy.
Material And Methods: All were investigated for abnormalities in complete haemogram, blood biochemistry, B12 levels, nerve conduction studies and cholinesterase levels. Results: There was distal muscle weakness in bilateral lower limbs with loss of deep tendon reflexes in lower limbs with EMG suggestive of axonal and demyelinating neuropathy with reduced RBC cholinesterase levels.
Discussion: From history and investigations it was found that the ingestion of wheat contaminated with tri-ortho-cresyl phosphate (TOCP) lead to axonal and demyelinating type of polyneuropathy.

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