Multidrug Resistant Extrapulmonary Tuberculosis at a Tertiary Care Centre
Abstract
Extrapulmonary manifestation of tuberculosis is prevalent in 10-34% of non HIV cases while it occurs in 50-70% of patients co-infected with HIV. Very limited data is available for drug resistance in extrapulmonary tuberculosis (EPTB). This was a prospective, observational study to assess the prevalence of multidrug resistant tuberculosis (MDRTB) from 90 clinically suspected cases of EPTB at a tertiary care centre in Mumbai. In the present study, M. tuberculosis was found in 18.88% of EPTB patients of which 47.05% were MDRTB. Maximum culture positivity (40%) was found in lymph node aspirates. High drug resistance to M. tuberculosis warrants periodic assessment of the trends of drug resistance to anti tuberculosis agents.
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2. Sharma SK, MohanA. Extrapulmonary tuberculosis. Indian J Med Res. 2004;120:316-353.
3. Revised National tuberculosis training manual for Mycobacterium tuberculosis culture and drug susceptibility testing. April 2009. Central TB division. Directorate General of health
services. Ministry of health and family welfare, Nirman Bhavan. New Delhi
4. Peto HM, Pratt RH, Harrington HA, LoBue PA, Armstrong LR. Epidemiology of extrapulmonary tuberculosis in the United States, 1993 to 2006. Clinical infectious disease. 2009; 49: 1350-1357.
5. Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, Rodrigues C. Xpert MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis. J Clin Microbiol. 2011; 49: 2540-45.
6. Maurya AK, Kant S, Nag VL, Kushwaha RAS, Dhole TN. Trends of anti-tuberculosis drug resistance pattern in new cases and previously treated cases of extrapulmonary tuberculosis cases in referral hospitals in northern India. J Postgraduate Medicine. 2012 ; 58: 185-189
7. Gurung R, Bhattacharya SK, Pradhan B, Gurung S, Singh Y. Phenotypic characterisation and drug sensitivity testing of mycobacteria isolated from extrapulmonary tuberculosis.
Kathmandu Univ Med J. 2010;57-61.
8. Sachdeva R, Gardre DV, Talwar V. Characterization and drug susceptibility patterns of extra-pulmonary mycobacterial isolates. Indian J Med Res. 2002;115:102-5.
9. Sethi S, Biswal M, Chatterjee SS, Mewara A, Gupta D, Kumar S, Singh K and Sharma M. Susceptibility pattern among pulmonary and extrapulmonary isolates of Mycobacterium tuberculosis in North India. African Journal of Microbiology Research. 2012; 6(15): 3696-3699.
10. Khan A, Usmani AQ, Sultana A, Hussain Z, Khan DA. Risk factors in development of multi drug resistant tuberculosis in the hospitalized patients. Pak Armed Forces Med J. 2005;55: 290-295.
11. Nakate P, Set R, Shastri J. Extrapulmonary tuberculosis in a tertiary care Hosp
Published
2019-07-30
How to Cite
Dr. Sonali Zadbuke, Set R, Khan N, Shastri J. (2019). Multidrug Resistant Extrapulmonary Tuberculosis at a Tertiary Care Centre. The Indian Practitioner, 69(2), 37-39. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/488
Section
Original Article
