Plexiform Neurofibromatosis A Surgical Answer for Management
Keywords:
Neurofibromatosis 1, Plexiform neurofibroma, Peripheral nervous system neoplasms
Abstract
Massive plexiform neurofibromatosis is an uncommon cutaneous manifestation of Type 1 neurofibromatosis. These tumours result in functional disability and severe disfigurement.
Due to the variable natural history of these lesions, the optimal management is not well defined and surgery is often delayed until significant disfigurement has occurred. The aim of
this report is to discuss the optimum timing of surgical intervention and to highlight the difficulties in dealing with an advanced lesion.
References
1. Huson SM, Harper PS, Compston DA. Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales. Brain. 1988;111:1355–81.
2. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA. 1997;278:51–7.
3. Woodruff JM. Pathology of tumours of the peripheral nerve sheath in type 1 neurofibromatosis. Am J Med Genet. 1999;89:23–30.
4. Friedrich RE, Korf B, Funsterer C, Mautner VF. Growth type of plexiformneurofibromas in NF1 determined on magnetic resonance images. Anticancer Res. 2003;23:949–52.
5. Friedrich RE, Schmelzle R, Hartmann M, Funsterer C, Mautner VF. Resection of small plexiformneurofibromas in neurofibromatosis type 1 children.World J SurgOncol. 2005;3:6.
6. Mukherji MM. Giant neurofibroma of the head and neck.Plast Recon Surg. 1974;53:184–9.
2. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA. 1997;278:51–7.
3. Woodruff JM. Pathology of tumours of the peripheral nerve sheath in type 1 neurofibromatosis. Am J Med Genet. 1999;89:23–30.
4. Friedrich RE, Korf B, Funsterer C, Mautner VF. Growth type of plexiformneurofibromas in NF1 determined on magnetic resonance images. Anticancer Res. 2003;23:949–52.
5. Friedrich RE, Schmelzle R, Hartmann M, Funsterer C, Mautner VF. Resection of small plexiformneurofibromas in neurofibromatosis type 1 children.World J SurgOncol. 2005;3:6.
6. Mukherji MM. Giant neurofibroma of the head and neck.Plast Recon Surg. 1974;53:184–9.
Published
2019-08-10
How to Cite
Avadhut N Dange, Chate N N, Gireboinwad S, Parab S V, Aiwale A. (2019). Plexiform Neurofibromatosis A Surgical Answer for Management. The Indian Practitioner, 68(8), 59-60. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/580
Section
Case Reports
