Role of Hypothyroidism in Onset and Survival in Cancers: Review of Literature

  • Dr. Jaisen Lokhande, Pawar S
Keywords: hypothyroidism, cancer, survival, propylthiouracil, animal studies

Abstract

Various experimental and clinical studies have investigated the role of thyroid hormone in normal as well as cancer cells. It has been observed that the presence of or the induction of hypothyroidism negatively influence certain types of cancers. This is seen as reduction in the occurrence of cancers, slowing of cancer growth and lesser incidence of metastasis in many cases. Few studies also observed an increase in the overall survival rate in cancer patients having incidental hypothyroidism. There are however few types of cancers which are rather negatively influenced by hypothyroidism. More studies are required to confirm the above and to investigate whether controlled induction of hypothyroidism can by any ways be used for increased survival.

References

1. Hellevik AI, Asvold BO, Bjøro T, Romundstad PR, Nilsen TI, Vatten LJ Thyroid function and cancer risk: a prospective population study. Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):570-4.
2. Theodossiou C, Skrepnik N, Robert EG, et al. Propylthiouracil-induced hypothyroidism reduces xenograft tumor growth in athymic nude mice. Cancer. 1999 Oct 15;86(8):1596-601.
3. Nelson M, Hercbergs A, Rybicki L, Strome M. Association between development of hypothyroidism and improved survival in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1041-6.
4. Davis FB, Tang HY, Shih A, et al. Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells. Cancer Res. 2006 Jul 15;66(14):7270-5.
5. Mishkin SY, Pollack R, Yalovsky MA, Morris HP, Mishkin S. Inhibition of local and metastatic hepatoma growth and prolongation of survival after induction of hypothyroidism. Cancer Res. 1981 Aug;41(8):3040-5.
6. Mishkin S, Morris HP, Yalovsky MA, Narasimha Murthy PV. Increased survival of rats bearing Morris hepatoma 7800 after induction of hypothyroidism. Cancer Res. 1979 Jul;39(7 Pt 1):2371-5.
7. Kumar MS, Chiang T, Deodhar SD. Enhancing effect of thyroxine on tumor growth and metastases in syngeneic mouse tumor systems. Cancer Res. 1979 Sep;39(9):3515-8.
8. Theodossiou C, Schwarzenberger P. Propylthiouracil reduces xenograft tumor growth in an athymic nude mouse prostate cancer model. Am J Med Sci. 2000 Feb;319(2):96-9.
9. Shoemaker JP, Dagher RK. Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate. J Natl Cancer Inst. 1979 Jun;62(6):1575-8.
10. Theodossiou C, Skrepnik N, Robert EG, Prasad C, Axelrad TW, Schapira DV, et al. Propylthiouracilinduced hypothyroidism reduces xenograft tumor growth in athymic nude mice. Cancer. 1999 Oct
15;86(8):1596-601.
11. Hercbergs AA, Goyal LK, Suh JH, Lee S, Reddy CA, Cohen BH, et al. Propylthiouracil-induced chemical hypothyroidism with high-dose tamoxifen prolongs survival in recurrent high grade glioma: a phase I/II study. Anticancer Res. 2003;23(1B):617-26.
12. Hercbergs A, Mason J, Reddy C. Proc Amer Assoc Cancer Res [homepage on the Internet]. 2004 [cited 2012 Jul 10].;45 Available from: http://www.aacrmeetingabstracts. org/cgi/content/abstract/2004/1/1024-a
13. Sandhu M., Zagorski B., Sykora K., Booth G., Brezden M. C. Autoimmune hypothyroidism protects against breast cancer development in the elderly. Journal of Clinical Oncology, 2006 ASCO Annual
Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 588.
14. Cristofanilli M, Yamamura Y, Kau SW, Bevers T, Strom S, Patangan M, et al. Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer. 2005;103(6):1122-8.
15. Baldazzi V, Tassi R, Lapini A, Santomaggio C, Carini M, Mazzanti R. The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: a prospective single-center study. Urol Oncol. 2012 Sep;30(5):704-10.
16. Atkins MB, Mier JW, Parkinson DR, et al. Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N Engl J Med. 1988;318:1557-1563.
17. Reid I, Sharpe I, McDevitt J, et al. Thyroid dysfunction can predict response to immunotherapy with interleukin- 2 and interferon-2. Br J Cancer. 1991;64: 915-918.
18. Weijl NI, Van Der Harst D, Brand A, et al. Hypothyroidism during immunotherapy with interleukin- 2 is associated with antithyroid antibodies and response to treatment. J Clin Oncol. 1993;11:1376-1383.
19. Hercbergs A. Thyroid disease/hypothyroidism correlates positively with survival in patients with metastatic renal cell cancer. Proc Am Assoc Cancer Res. 1998;39:482.
20. Mitra, I. and Hayward, J. L. Hypothalamic pituitary thyroid axis in breast cancer. Lancet. 1974;2:885-89.
21. Itoh K, Maruchi N. Breast cancer in patients with Hashimoto’s thyroiditis. Lancet. 1975;2:1109–1112.
22. Martínez-Iglesias O, García-Silva S, Regadera J, Aranda A. Hypothyroidism enhances tumor invasiveness and metastasis development. PLoS One. 2009;4(7):e6428.
23. Reddy A, Dash C, Leerapun A, Mettler TA, Stadheim LM, Lazaridis KN, et al. Hypothyroidism: a possible risk factor for liver cancer in patients with no known underlying cause of liver disease. Clin Gastroenterol Hepatol. 2007;5(1):118-23.
Published
2019-09-03
How to Cite
Dr. Jaisen Lokhande, Pawar S. (2019). Role of Hypothyroidism in Onset and Survival in Cancers: Review of Literature. The Indian Practitioner, 68(1), 31-35. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/691