An unusual presentation of a case of primary plasma cell leukaemia in a psychotic patient with associated tuberculosis
Keywords:
Primary, Plasma cell, leukemia, Multiple myeloma
Abstract
Plasma cell leukaemia (PCL) is a rare disorder that can develop spontaneously (primary) or evolve in patients with multiple myeloma (secondary). Histogenetically, plasma cell leukaemia is derived from terminally differentiated B cells. It is diagnosed by the presence of absolute plasma cell count > 2000/
cumm or > 20% circulating plasma cells in blood. We report a rare case of primary plasma cell leukaemia in a patient of bipolar affective disorder presenting with weakness of lower limbs, fatigability, generalized myalgia and mood changes. She was a known case of pulmonary tuberculosis. There was no previous history of multiple myeloma. Clinical spectrum, cytomorphological features and prognosis of PCL are discussed.
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3. Jain D, Singh T, Akhila L, Ghosh N. Primary plasma cell leukemia in a 30-year-old woman. Indian J Pathol Microbiol. 2008;51(3):456-457.
4. Deodhar SS. Haematopathology in general pathology and pathology of systems eds. Deodhare SG.Popular Prakashan, Mumbai. 2002;(51)2:2005-2141.
5. Costello R, Sainty D, Bouabdallah R, Fermand JP, Delmer A, Divini M, et al. Primary plasma cell leukemia: A report of 18 cases. Leuk Res.2001;25:103-107.
6. Desai SR, Angarkar NN, Kulkarni AG. Primary plasma cell leukemia. J Assoc Physic India.2004; 52:510.
7. Badhe BA, Basu D, Toi PCh, Dutta PK, Ghotekar LH. Plasma cell leukemia - a case report.Ind J Pathol and Microbiol. 2003;46 (3):484-487.
8. Reed M, McKenna RW, Bridges R, Parkin J, Frizzera G, Brunning RD. Morohologic manifestations of monoclonal gammopathies. Am J Clin Pathol. 1981;76(1):8-
23
9. Pasqualetti P, Casale R, Collacciani A, Abruzzo BP, olantonio D. Multiple myeloma: relationship between survival and cellular morphology. Am J Hematol. 1990;33(2):145-147.
Published
2019-09-03
How to Cite
Anshu Gupta, Chhavi G, Anju K. (2019). An unusual presentation of a case of primary plasma cell leukaemia in a psychotic patient with associated tuberculosis. The Indian Practitioner, 68(1), 46-49. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/695
Section
Case Reports
