Olanzapine induced Diabetic ketoacidosis: Inadvertent Suffering
Abstract
A 24 year old male was admitted to the hospital, suffering from compensated ketoacidosis and high blood sugar levels. On detailed history it was revealed that he was on olanzapine for more than 6 months as a part of treatment for bipolar disorder. Blood sugars were initially managed by intravenous and later by subcutaneous actrapid insulin. A proposed diagnosis of type I Diabetes mellitus vs Olanzapine induced DKA was put forward. Patient’s requirement of insulin came down after olanzapine was discontinued.
References
1. Sweetman S C. Anxiolytic Sedatives Hypnotics and Antipsychotics In: Martindale: The Complete Drug Reference 36th ed. Pharmaceutical Press, China 2009:1012-14
2. Koller E A, Doraiswamy M P. Olanzapine-Associated Diabetes Mellitus. Pharmacotherapy: The Journal of Human Pharmacology and Drug therapy 2002; 22/7: pages 841–52
3. O’Byrne S, Feely J. Effects of drugs on glucose tolerance in noninsulin- dependent diabetes (parts I and II). Drugs 1990;40:203-19
4. Barrett E, Blonde L, Clement S, Davis J, Devlin J, Kane J, Klein S, Torrey W, Clark N G. Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes: Diabetes Care 2004; 27/ 2 , 596-601
2. Koller E A, Doraiswamy M P. Olanzapine-Associated Diabetes Mellitus. Pharmacotherapy: The Journal of Human Pharmacology and Drug therapy 2002; 22/7: pages 841–52
3. O’Byrne S, Feely J. Effects of drugs on glucose tolerance in noninsulin- dependent diabetes (parts I and II). Drugs 1990;40:203-19
4. Barrett E, Blonde L, Clement S, Davis J, Devlin J, Kane J, Klein S, Torrey W, Clark N G. Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes: Diabetes Care 2004; 27/ 2 , 596-601
Published
2019-09-06
How to Cite
Kavita Krishna, Gadkari N, Jain G N, Patodia B, Doshi V. (2019). Olanzapine induced Diabetic ketoacidosis: Inadvertent Suffering. The Indian Practitioner, 67(10), 639-640. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/740
Section
Case Reports
