Polycystic Ovary Syndrome and Leucocytosis
Abstract
Polycystic ovary syndrome (PCOS) is a complex heterogeneous female reproductive endocrine disorder with multiple pathological mechanisms. Persistent leucocytosis, reflecting an underlying
inflammation, is well recorded in obesity and diabetes; diseases with an underlying Insulin resistance (IR). Leucocytosis in PCOS has not been widely studied in spite of IR being considered as
the important aetiopathological mechanism. The present communication explores the occurrence of leucocytosis in thirty patients of PCOS as compared to that in twenty six healthy regularly menstruating women.
References
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14. WHO. Physical status. The use and interpretation of anthropometry- Report of a WHO expert committee. WHO Technical Series 854, Geneva World Health Organization; 1995.
15. Misra A. Revision of cutoff of body mass index to define overweight and obesity are needed for the Asian- Indian groups. Int J Obesity. 2003; 27 : 1294-1296.
16. Vaidya RA, Pandey SN, and Vaidya ADB. Polycystic ovary syndrome:Is it a chronic inflammatory disease?Chapter 3, ECAB Clinical Update: Obstetrics and Gynecology. 2008;1:42-73.
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18. Phelan N1, O’Connor A, Kyaw Tun T, Correia N, Boran G, Roche HM, Gibney J. Leucocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance. Clin Endocrinol (Oxf). 2013 Jan; 78(1):107-13.
19. Morton A. Neutrophil leucocytosis and polycystic ovarian syndrome--could elevated noradrenaline levels due to obstructive sleep apnoea be a contributing mechanism? Clin Endocrinol (Oxf). 2013 Oct; 79(4):591.
20. Hansen LK, Grimm RH jr, Neaton JD. The relationship of white blood cell count to other cardiovascular risk factors. Int J Epidemiol. 1990; 19:881–888.
21. Ohshita K, Yamane K, Hanafusa M, Mori H, Mito K, Okubo M et al Elevated White Blood Cell Count in Subjects with Impaired Glucose Tolerance. Diabetes Care. 2004; 27:491–496.
2. Perfetto F, Mancuso F, Tarquini R. Leukocytosis and hyperleptinemia in obesity. Haematologica. 2002; 87 :( 05) ELT25.
3. Herishanu Y, Rogowski O, Polliack A, Marilus R. Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia. Eur J Haematol. 2006; 76:516-20.
4. Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002; 51:455–461.
5. Sefil F, Ulutas KT, Dokuyucu R, Sumbul AT, Yengil E, Yagiz AE, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in Patients with type 2 diabetes mellitus. Journal of International Medical Research. 2014; 42:581-588.
6. Twig, G, Afek A, Shamiss A, Derazne E, Tzur D, Gordon B, Tirosh A. White Blood Cells Count and Incidence of Type 2 Diabetes in Young Men. Diabetes Care. 2013; 36: 276-282.
7. Dandona P., Aljada, A., Bandyopadhyay, A. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol. 2004; 25:4–7.
8. Shoelson SE, Lee J, Goldfine AB.Inflammation and insulin resistance. J Clin Invest. 2006 July; 116(7):1793- 801.
9. Bastard J P, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B.Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17:4-12.
10. Halen A, Laven J.SE, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003; 9: 505- 514.
11. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility. 2004; 81: 19-25.
12. Godkar P.B.and Godkar D.P. Section III Hematology, In: Godkar P.B.and Godkar D.P editors. Textbook of Medical Laboratory, Second Edition, Bhalani Publishing House Mumbai, 2003; p. 721:774.
13. Shringi MS, Vaidya RA, Vaidya AB et al. Insulin resistance in polycystic ovarian syndrome. Indian Journal of endocrinology and metabolism. 2003; 1: 19-23.
14. WHO. Physical status. The use and interpretation of anthropometry- Report of a WHO expert committee. WHO Technical Series 854, Geneva World Health Organization; 1995.
15. Misra A. Revision of cutoff of body mass index to define overweight and obesity are needed for the Asian- Indian groups. Int J Obesity. 2003; 27 : 1294-1296.
16. Vaidya RA, Pandey SN, and Vaidya ADB. Polycystic ovary syndrome:Is it a chronic inflammatory disease?Chapter 3, ECAB Clinical Update: Obstetrics and Gynecology. 2008;1:42-73.
17. Herlihy AC1, Kelly RE, Hogan JL, O’Connor N, Farah N, Turner MJ, Polycystic ovary syndrome and the peripheral blood white cell count. J Obstet Gynaecol. 2011; 31(3):242-4.
18. Phelan N1, O’Connor A, Kyaw Tun T, Correia N, Boran G, Roche HM, Gibney J. Leucocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance. Clin Endocrinol (Oxf). 2013 Jan; 78(1):107-13.
19. Morton A. Neutrophil leucocytosis and polycystic ovarian syndrome--could elevated noradrenaline levels due to obstructive sleep apnoea be a contributing mechanism? Clin Endocrinol (Oxf). 2013 Oct; 79(4):591.
20. Hansen LK, Grimm RH jr, Neaton JD. The relationship of white blood cell count to other cardiovascular risk factors. Int J Epidemiol. 1990; 19:881–888.
21. Ohshita K, Yamane K, Hanafusa M, Mori H, Mito K, Okubo M et al Elevated White Blood Cell Count in Subjects with Impaired Glucose Tolerance. Diabetes Care. 2004; 27:491–496.
Published
2019-09-09
How to Cite
Priyanka Mertia, Agashe S, Rege N , Vaidya R. (2019). Polycystic Ovary Syndrome and Leucocytosis. The Indian Practitioner, 67(8), 483-485. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/763
Section
Original Article
