Fulvic Acid – A Natural and Multifaceted Approach to the Management of Inflammatory Dermatosis
Keywords:
Fulvic acid, Inflammatory dermatosis, Eczema, Humic, Atopic
Abstract
Fulvic Acid is a part of Humic substances found in the humus of soil. It has the advantage of higher oxygen content, water solubility at all pH, and low molecular weight as compared to other humic substances. Fulvic acid has been studied for its various clinical benefits including Anti-inflammatory, Astringent, Anti-oxidant,
Anti-allergic and Anti-microbial properties which makes it a useful option in the management of inflammatory conditions of the skin (Inflammatory Dermatosis like Eczema, Atopic dermatitis and Psoriasis). Its effectiveness and tolerance have been demonstrated in clinical studies, and its health benefits have also been known part of traditional medicine in India. Topical cream/lotion formulations of fulvic acid in a moisturizing base is now available in India. Fulvic acid can serve to be of added value over emollients alone in managing skin inflammation, and also be beneficial for long term daily application in pre-disposed patients.
References
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2. Schmidt HP.Humus or Famine? the Biochar Journal 2015, Arbaz, Switzerland
3. Schnitzer M. Recent findings of the characterization of humic substances extracted from soils from widely differing climatic zones. Proceedings of the Symposium on Soil Organic Matter Studies. Braunsweig. 1977: 117- 131.
4. Aiken GR, McKnight DM, MacCarthy P. Low molecular weight Humic substances of soil, sediment and water, New York. Wiley-Interscience 1985.
5. Azo S, Sakai I. Absorption by cells -Studies on the physiological effects of humic acid. Part 1. Uptake of humic acid by crop plants and its physiological effects. Soil Science and Plant Nutrition. 1963; 9(3), 1-91. (Tokyo)
6. Morales OY, Navarretel JM, Gracia I, Macias L, Rivera M, Sanchez F. Effect of Fulvic acids on the electrolytes physiology in vertebrates. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2011 Oct; 652(1):838-40
7. Wollina U. Peat: A Natural Source for Dermatocosmetics and Dermatotherapeutics. J CutanAesthet Surg. 2009 Jan-Jun; 2(1): 17–20
8. Mirza MA, Ahmad N, Agarwal AP, Mahmood D, Anwer MK. Comparative evaluation of humic substances in oral drug delivery. Results in Pharma Sciences. 2011 May; 1(1), 16-26
9. Vucskits AV, Hullar I, Bersenyi A, Andrasofszky E, Kulcsar M, Szabo J. Effect of Fulvic and humic acids on performance, immune response and thyroid function in rats. J AnimPhysiolAnimNutr (Berl) 94, 721–728
10. Winkler J, Ghosh S. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018; ID 5391014: 1-7
11. Van Rensburg CEJ, Malfeld SCK, Decker J. Topical application of oxiFulvic acid suppresses the cutaneous immune response in mice. Drug Dev Res. 2001; 53(1):29–32.
12. Effect of Fulvic acid on ultraviolet induced skin aging: The effect of Fulvic acid on fibroblasts and matrix metalloproteinase. Nishinihon Journal of Dermatology. 2012; 74(4)427--431
13. Snyman JR, Dekker J, Malfeld SCK, van Rensburg CEJ. Pilot study to evaluate the safety and therapeutic efficacy of topical oxiFulvic acid in atopic volunteers. Drug Development Research.2002;57(1):40–43
14. Hideko M, Parida Y, Junkyu H, Masuo O, Hideyuki S, Hiroko I. Properties of Fulvic Acid Extracted from Excess Sludge and Its Inhibiting Effect on β-Hexosaminidase Release, Bioscience, Biotechnology, and Biochemistry. 2009; 73 (10): 2210-2216
15. Yamada P, Isoda H, Han JK, Talorete TP, Abe Y. Inhibitory effect of Fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells. BiosciBiotechnolBiochem. 2007 May;71(5):1294-305.
16. Van Rensburg CEJ, Van Straten A, Dekker J. An in vitro investigation of the antimicrobial activity of oxiFulvic acid. J AntimicrobChemother. 2000; 46: 853-854
17. Kotwal GJ. Natural Antivirals against Human Viruses. Virol Mycol. 2014; 3(2): 1000e107
18. Sabi R, Vrey P, van Rensburg CEJ. Carbohydrate-derived Fulvic acid (CHD-FA) inhibits carrageenan-induced inflammation and enhances wound healing: efficacy and toxicity study in rats. Drug Development Research. 2012;73(1):18–23
19. Zhao Y, Paderu P, Delmas G, Dolgov E, Lee MH, Senter M. Carbohydrate-derived Fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. Journal of Trauma and Acute Care Surgery. 2015;79(4):S121–S129
20. Gandy JJ, Snyman JR, Van Rensburg CEJ. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived Fulvic acid in topical treatment of eczema. ClinCosmetInvestigDermatol. 2011;4:145-8.
21. Meena H, Pandey HK, Arya MC, Ahmed Z. Shilajit: A panacea for high-altitude problems. Int J Ayurveda Res. 2010;1(1):37–40. doi:10.4103/0974-7788.59942
22. ByungWan J, JunHo J, Yunsung L. Development of functional nourishing cream using fulvic acid. Journal of Pharmacy and Biological Sciences (IOSR-JPBS). 2017 May-June; 12(3)III: 47-58.
2. Schmidt HP.Humus or Famine? the Biochar Journal 2015, Arbaz, Switzerland
3. Schnitzer M. Recent findings of the characterization of humic substances extracted from soils from widely differing climatic zones. Proceedings of the Symposium on Soil Organic Matter Studies. Braunsweig. 1977: 117- 131.
4. Aiken GR, McKnight DM, MacCarthy P. Low molecular weight Humic substances of soil, sediment and water, New York. Wiley-Interscience 1985.
5. Azo S, Sakai I. Absorption by cells -Studies on the physiological effects of humic acid. Part 1. Uptake of humic acid by crop plants and its physiological effects. Soil Science and Plant Nutrition. 1963; 9(3), 1-91. (Tokyo)
6. Morales OY, Navarretel JM, Gracia I, Macias L, Rivera M, Sanchez F. Effect of Fulvic acids on the electrolytes physiology in vertebrates. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2011 Oct; 652(1):838-40
7. Wollina U. Peat: A Natural Source for Dermatocosmetics and Dermatotherapeutics. J CutanAesthet Surg. 2009 Jan-Jun; 2(1): 17–20
8. Mirza MA, Ahmad N, Agarwal AP, Mahmood D, Anwer MK. Comparative evaluation of humic substances in oral drug delivery. Results in Pharma Sciences. 2011 May; 1(1), 16-26
9. Vucskits AV, Hullar I, Bersenyi A, Andrasofszky E, Kulcsar M, Szabo J. Effect of Fulvic and humic acids on performance, immune response and thyroid function in rats. J AnimPhysiolAnimNutr (Berl) 94, 721–728
10. Winkler J, Ghosh S. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018; ID 5391014: 1-7
11. Van Rensburg CEJ, Malfeld SCK, Decker J. Topical application of oxiFulvic acid suppresses the cutaneous immune response in mice. Drug Dev Res. 2001; 53(1):29–32.
12. Effect of Fulvic acid on ultraviolet induced skin aging: The effect of Fulvic acid on fibroblasts and matrix metalloproteinase. Nishinihon Journal of Dermatology. 2012; 74(4)427--431
13. Snyman JR, Dekker J, Malfeld SCK, van Rensburg CEJ. Pilot study to evaluate the safety and therapeutic efficacy of topical oxiFulvic acid in atopic volunteers. Drug Development Research.2002;57(1):40–43
14. Hideko M, Parida Y, Junkyu H, Masuo O, Hideyuki S, Hiroko I. Properties of Fulvic Acid Extracted from Excess Sludge and Its Inhibiting Effect on β-Hexosaminidase Release, Bioscience, Biotechnology, and Biochemistry. 2009; 73 (10): 2210-2216
15. Yamada P, Isoda H, Han JK, Talorete TP, Abe Y. Inhibitory effect of Fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells. BiosciBiotechnolBiochem. 2007 May;71(5):1294-305.
16. Van Rensburg CEJ, Van Straten A, Dekker J. An in vitro investigation of the antimicrobial activity of oxiFulvic acid. J AntimicrobChemother. 2000; 46: 853-854
17. Kotwal GJ. Natural Antivirals against Human Viruses. Virol Mycol. 2014; 3(2): 1000e107
18. Sabi R, Vrey P, van Rensburg CEJ. Carbohydrate-derived Fulvic acid (CHD-FA) inhibits carrageenan-induced inflammation and enhances wound healing: efficacy and toxicity study in rats. Drug Development Research. 2012;73(1):18–23
19. Zhao Y, Paderu P, Delmas G, Dolgov E, Lee MH, Senter M. Carbohydrate-derived Fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. Journal of Trauma and Acute Care Surgery. 2015;79(4):S121–S129
20. Gandy JJ, Snyman JR, Van Rensburg CEJ. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived Fulvic acid in topical treatment of eczema. ClinCosmetInvestigDermatol. 2011;4:145-8.
21. Meena H, Pandey HK, Arya MC, Ahmed Z. Shilajit: A panacea for high-altitude problems. Int J Ayurveda Res. 2010;1(1):37–40. doi:10.4103/0974-7788.59942
22. ByungWan J, JunHo J, Yunsung L. Development of functional nourishing cream using fulvic acid. Journal of Pharmacy and Biological Sciences (IOSR-JPBS). 2017 May-June; 12(3)III: 47-58.
Published
2019-11-15
How to Cite
Varsha Narayanan. (2019). Fulvic Acid – A Natural and Multifaceted Approach to the Management of Inflammatory Dermatosis. The Indian Practitioner, 72(10), 28-31. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/860
Section
Review article
