Leukemoid Reaction in Chikungunya Fever : A Case Report
Keywords:
Chronic myelogenous leukaemia, Chronic neutrophilic leukaemia, Neutrophil alkaline phosphatase, Total leukocyte counts, Differential leukocyte counts, Renal function test, Liver function test, Peripheral blood smear
Abstract
Chikungunya is a viral illness caused by an arbovirus which is transmitted by Aedes mosquito. Fever and
polyarthralgia are hallmark of this viral illness. Viral infections are generally associated with leucopenia
and bacterial infections with leukocytosis. Persistent neutrophilia with cell counts of ≥30,000 – 50,000/μL is
called a leukemoid reaction. Leukocytosis is common in Chikungunya but leukemoid reaction has not been
reported . Our patient presented with high grade fever and symmetrical polyarthritis. Blood investigation
showed Leukemoid reaction and after extensive work up a diagnosis of chikungunya was made.
References
1] Krumbhaar EB. Leukemoid blood pictures in various clinical conditions. Am J Med Sci. 1926;172:519–33. [Google Scholar]
2] Disorder of granulocytes and monocytes, Stevens M Holland and John I Gallin,page 398, Harrison’s Principles of Internal Medicine 20th edition.
3] Nimieri HS, Makoni SN, Madziwa FH, Nemiary DS. Leukemoid reaction response to chaemotherapy and radiotherapy in a patient with cervical carcinoma. Ann Haematol.
2003;82:316–17. [PubMed] [Google Scholar]
4] Reilly JT. Chronic neutrophilic leukaemia: a distinct clinical entity? Br J Haematol. 2002;116:10–8. [PubMed] [Google Scholar]
5] Mycyk MB, Drendel A, Sigg T, Leikin JB. Leukemoid response in ethylene glycol toxication. Vet Hum Toxicol. 2002;44:304–06. [PubMed] [Google Scholar]
6] Ganti AK, Potti A, Mehdi S. Uncommon syndromes and treatment manifestations of malignancy: case 2. Metastatic non-small-cell lung cancer presenting with leukocytosis. J Clin Oncol. 2003;21(1):168–70. [PubMed] [Google Scholar]
7] Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394–98. [PubMed] [Google Scholar]
8] Thiruvengadam KV, Kalyanasundaram V, Rajgopal J. Clinical and pathological studies on Chikungunya fever in Madras city. Indian J Med Res. 1965;53(8):729–44. [PubMed] [Google Scholar]
9] Hill JM, Duncan CN. Leukemoid reactions. Am J Med Sci. 1941;201:847. [Google Scholar].
2] Disorder of granulocytes and monocytes, Stevens M Holland and John I Gallin,page 398, Harrison’s Principles of Internal Medicine 20th edition.
3] Nimieri HS, Makoni SN, Madziwa FH, Nemiary DS. Leukemoid reaction response to chaemotherapy and radiotherapy in a patient with cervical carcinoma. Ann Haematol.
2003;82:316–17. [PubMed] [Google Scholar]
4] Reilly JT. Chronic neutrophilic leukaemia: a distinct clinical entity? Br J Haematol. 2002;116:10–8. [PubMed] [Google Scholar]
5] Mycyk MB, Drendel A, Sigg T, Leikin JB. Leukemoid response in ethylene glycol toxication. Vet Hum Toxicol. 2002;44:304–06. [PubMed] [Google Scholar]
6] Ganti AK, Potti A, Mehdi S. Uncommon syndromes and treatment manifestations of malignancy: case 2. Metastatic non-small-cell lung cancer presenting with leukocytosis. J Clin Oncol. 2003;21(1):168–70. [PubMed] [Google Scholar]
7] Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Giamarellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med. 2006;17(6):394–98. [PubMed] [Google Scholar]
8] Thiruvengadam KV, Kalyanasundaram V, Rajgopal J. Clinical and pathological studies on Chikungunya fever in Madras city. Indian J Med Res. 1965;53(8):729–44. [PubMed] [Google Scholar]
9] Hill JM, Duncan CN. Leukemoid reactions. Am J Med Sci. 1941;201:847. [Google Scholar].
Published
2019-11-26
How to Cite
Dr Kishore Kumar Sharma, Dr. Maniram Kumhar , Dr Mayank Shrivastava , Dr. Harsh Tak. (2019). Leukemoid Reaction in Chikungunya Fever : A Case Report. The Indian Practitioner, 72(11), 24-26. Retrieved from https://articles.theindianpractitioner.com/index.php/tip/article/view/871
Section
Case Reports
