A Review of Digestive Enzyme and Probiotic Supplementation for Functional Gastrointestinal Disorders

Amit Qamra ,NK Soni, HH Trivedi , Sanjay Kumar , Anukalp Prakash, Soumen Roy  , Supriyo Mukherjee

Amit Qamra ,NK Soni, HH Trivedi , Sanjay Kumar , Anukalp Prakash, Soumen Roy , Supriyo Mukherjee

Keywords: Digestive enzyme, Probiotics, Functional Dyspepsia, Indigestion.

Abstract

Functional gastrointestinal disorders (FGIDs) also known as disorders of gut-brain interaction are chronic,
recurrent disorders with no identifiable underlying pathology. The FGID with upper abdominal pain and discomfort
is the hallmark feature of functional dyspepsia. Around 11-30% prevalence of functional dyspepsia
is reported worldwide. One of the unique features of functional dyspepsia is transient deficiency of digestive
enzymes in the system. Digestive enzymes are produced and secreted by the gastrointestinal system
to break down fats, proteins, and carbohydrates, to accomplish digestion and, afterwards, the absorption
of nutrients. Supplementation with digestive enzymes could provide management of disorders caused by
impaired digestive function. Various formulations of enzyme supplementation are available commercially
in the market, and are currently used in clinical practice for the management of several digestive diseases.
Probiotics have multi-faceted role, helping to restore the gut microbiota.
This review elaborates the potential of multi digestive enzymes along with probiotics in the management of
digestive diseases and dyspepsia.
Conflicts of Interest: None.

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